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References:

Kuo TB, Lin T, Yang CC, Li CL, Chen CF, Chou P. Effect of aging on gender differences in neural control of heart rate. Am J Physiol. 1999; 277:H2233–39. PMID:10600841
Stein PK, Freedland KE, Skala JA, Carney RM, Davila Roman V, Rich MW, Kleiger RE. Heart rate variability is independent of age, gender, and race in congestive heart failure with a recent acute exacerbation. Am J Cardiol. 1997; 79:511–12. https://doi.org/10.1016/S0002-9149(96)00798-9 PMID:9052363
George MS, Sackeim HA, Rush AJ, Marangell LB, Nahas Z, Husain MM, Lisanby S, Burt T, Goldman J, Ballenger JC. Vagus nerve stimulation: a new tool for brain research and therapy. Biol Psychiatry. 2000; 47:287–95. https://doi.org/10.1016/S0006- 3223(99)00308-X PMID:10686263
Allostatic Load and Its Impact on Health: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/32799204/
Crowley K. Sleep and sleep disorders in older adults. Neuropsychol Rev. 2011; 21:41–53. https://doi.org/10.1007/s11065-010-9154-6
PMID:21225347
Bibevski S, Dunlap ME. Evidence for impaired vagus nerve activity in heart failure. Heart Fail Rev. 2011; 16:129–35. https://doi.org/10.1007/s10741-010- 9190-6 PMID:20820912
Kearney MT, Zaman A, Eckberg DL, Lee AJ, Fox KA, Shah AM, Prescott RJ, Shell WE, Charuvastra E, Callahan TS, Brooksby WP, Wright DJ, Gall NP, Nolan J. Cardiac size, autonomic function, and 5-year follow-up of chronic heart failure patients with severe prolongation of ventricular activation. J Card Fail. 2003; 9:93–99. https://doi.org/10.1054/jcaf.2003.15 PMID:12751129
Trifilio, E., Shortell, D., Olshan, S., Coyne, J., Lamb, D., Porges, E., & Williamson, J. (2023). Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging. Frontiers in Neuroscience, 17, 1184051. https://doi.org/10.3389/fnins.2023.1184051
Jacobs, H. I., Riphagen, J. M., Razat, C. M., Wiese, S., & Sack, A. T. (2015). Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. Neurobiology of Aging, 36(5), 1860-1867.
Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study https://www.thelancet.com/journals/landig/article/PIIS2589-7500(20)30246-6/fulltext
Clancy JA, Mary DA, Witte KK, Greenwood JP, Deuchars SA, Deuchars J. Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity. Brain Stimulat. 2014; 7:871–77. https://doi.org/10.1016/j.brs.2014.07.031 PMID:25164906 https://pmc.ncbi.nlm.nih.gov/articles/PMC6682519/
Waveform R1, 30Hz 200us- Improved Age-related autonomic, mood, and sleep changes, fatigue mitigation. Bretherton B, Atkinson L, Murray A, Clancy J, Deuchars S, Deuchars J. Effects of transcutaneous vagus nerve stimulation in individuals aged 55 years or above: potential benefits of daily stimulation. Aging (Albany NY). 2019 Jul 30; 11:4836-4857 . https://doi.org/10.18632/aging.102074
Neuvana & NFL Alumni Health – “Study to Improve Sleep & Reduce Stress in Former Players” (Study overview and methodology) https://nflalumnihealth.org/neuvana/
Note: Official detailed results were circulated via NFL Alumni Health communications in 2023; the above figures are as reported by Neuvana’s study summary.
Neuvana’s own pilot studies, not from peer-reviewed publications. / Observational Study (Internal study): Professional Athlete Alumni Sleep and Stress Study /Proof of Concept in Recovering Addicts (Internal Study): POC Study in Addiction Recovery
Taylor CB. Depression, heart rate related variables and cardiovascular disease. Int J Psychophysiol. 2010; 78:80–88. https://doi.org/10.1016/j.ijpsycho.2010.04.006 PMID:2042086. Barton DA, Dawood T, Lambert EA, Esler MD, Haikerwal D, Brenchley C, Socratous F, Kaye DM, Schlaich MP, Hickie I, Lambert GW. Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk? J Hypertens. 2007; 25:2117–24. https://doi.org/10.1097/HJH.0b013e32829baae7 PMID:17885556
Antonino D, Teixeira AL, Maia-Lopes PM, Souza MC, Sabino-Carvalho JL, Murray AR, Deuchars J,Vianna LC. Non-invasive vagus nerve stimulation acutely improves spontaneous cardiac baroreflex sensitivity in healthy young men: A randomized placebo controlled trial. Brain Stimulat. 2017; 10:875–81. https://doi.org/10.1016/j.brs.2017.05.006 PMID:28566194
Jiao Y, Guo X, Luo M, et al. Effect of Transcutaneous Vagus Nerve Stimulation at Auricular Concha for Insomnia: A Randomized Clinical Trial [published correction appears in Evid Based Complement Alternat Med. 2020 Nov 22;2020:2536573]. Evid Based Complement Alternat Med. 2020;2020:6049891. Published 2020 Aug 6. doi:10.1155/2020/6049891
1. Kuo TB, Lin T, Yang CC, Li CL, Chen CF, Chou P. Effect of aging on gender differences in neural control of heart rate. Am J Physiol. 1999; 277:H2233–39. PMID:10600841
Neuvana & NFL Alumni Health – “Study to Improve Sleep & Reduce Stress in Former Players” (Study overview and methodology) nflalumnihealth.org / Neuvana Life press interview – “Stress Reduction & Better Sleep with Xen” (Dr. Cartledge on study goals and outcomes) neuvanalife.com / Neuvana Press Release – “Neuvana’s Xen Device Delivers Wellness Benefits”/ https://neuvanalife.com/blogs/news/stress-reduction-and-better-sleep-get-this-and-more-with-neuvana-s-xen-device?srsltid=AfmBOoof58RI38Q5BuBVHkWBm_VMHdTtb0Ota_0EdlLN-EJbKgeibe4d#:~:text=We%20recommend%20fifteen%20minutes%20twice,mundane%20like%20doing%20your%20taxes"
Marta Jackowska, Julian Koenig, Veronika Vasendova, Vera K. Jandackova. A two-week course of transcutaneous vagal nerve stimulation improves global sleep: Findings from a randomised trial in community-dwelling adults. Autonomic Neuroscience. Volume 240, 2022